SCHEMBL9712144

SCHEMBL9712144

CCCC/C=C(\F)C(=O)O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EP300 Q09472 1/20 0.52
GABRR1 P24046 1/20 0.48
GRIK1 P39086 1/20 0.46
F7 P08709 2/20 0.41
F3 P13726 2/20 0.41
TSHR P16473 1/20 0.39
TERT O14746 3/20 0.36
PTPN1 P18031 3/20 0.36
PPARG P37231 3/20 0.36
PPARD Q03181 3/20 0.36
PPARA Q07869 3/20 0.36
MAPT P10636 2/20 0.36
BLM P54132 2/20 0.36
HSD17B10 Q99714 2/20 0.36
FABP4 P15090 2/20 0.36
GMNN O75496 1/20 0.36
USP2 O75604 1/20 0.36
LMNA P02545 1/20 0.36
CYP1A2 P05177 1/20 0.36
POLB P06746 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15546702 1.00 EP300 (0.52) EP300GABRR1GRIK1F7F3
SCHEMBL7643972 0.93 EP300 (0.61) EP300GABRR1F7F3TERT
SCHEMBL7643975 0.93 EP300 (0.61) EP300GABRR1F7F3TERT
SCHEMBL6138616 0.91 EP300 (0.64) EP300GABRR1F7F3TERT
SCHEMBL6924911 0.91 EP300 (0.64) EP300GABRR1F7F3TERT
SCHEMBL16288161 0.91 EP300 (0.64) EP300GABRR1F7F3TERT
SCHEMBL8948205 0.91 EP300 (0.64) EP300GABRR1F7F3TERT
SCHEMBL8948204 0.91 EP300 (0.64) EP300GABRR1F7F3TERT
SCHEMBL16288157 0.91 EP300 (0.64) EP300GABRR1F7F3TERT
SCHEMBL16288159 0.91 EP300 (0.64) EP300GABRR1F7F3TERT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150196585-A1 COMPOSITIONS COMPRISING CROSSLINKED CATION-BINDING POLYMERS AND USES THEREOF VIFOR (INTERNATIONAL) LTD. (CH) 2015-07-16 US disclosed
US-20150183908-A1 COMPOSITIONS COMPRISING CROSSLINKED CATION-BINDING POLYMERS AND USES THEREOF VIFOR (INTERNATIONAL) LTD. (CH) 2015-07-02 US disclosed
EP-2874633-A1 COMPOSITIONS COMPRISING CROSSLINKED CATION-BINDING POLYMERS Relypsa, Inc. (US) 2015-05-27 EP disclosed
WO-2014015244-A1 COMPOSITIONS COMPRISING CROSSLINKED CATION-BINDING POLYMERS SORBENT THERAPEUTICS, INC. (US) 2014-01-23 WO disclosed
WO-2014015240-A1 COMPOSITIONS COMPRISING CROSSLINKED CATION-BINDING POLYMERS SORBENT THERAPEUTICS, INC. (US) 2014-01-23 WO disclosed
WO-1992021492-A1 MOISTURE RESISTANT GLASS ARTICLE ADVANCED GLASS TREATMENT SYSTEMS (US) 1992-12-10 WO disclosed
EP-0103436-A2 Process for preparing 5-perfluoroalkyl-5,6-dihydrouracil derivatives and compounds for use therein SAGAMI CHEMICAL RESEARCH CENTER (JP) 1984-03-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150183908-A1 COMPOSITIONS COMPRISING CROSSLINKED CATION-BINDING POLYMERS AND USES THEREOF PICALM, ORAI1, KCNN3 EP300 3142/4885GABRR1 451/4885GRIK1 132/4885
US-20150196585-A1 COMPOSITIONS COMPRISING CROSSLINKED CATION-BINDING POLYMERS AND USES THEREOF SSB, PARG, HLA-DRB1 EP300 1514/4885GABRR1 304/4885GRIK1 195/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.