SCHEMBL9712377

SCHEMBL9712377

Cc1cc(C(=O)c2ccccc2Cl)ccc1C(=O)Cl

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.54
ALDH1A1 P00352 8/20 0.51
POLB P06746 3/20 0.46
MTNR1A P48039 1/20 0.46
MTNR1B P49286 1/20 0.46
CDC25A P30304 1/20 0.45
CDC25B P30305 1/20 0.45
HSD17B10 Q99714 1/20 0.45
CES2 O00748 2/20 0.44
CES1 P23141 2/20 0.44
RECQL P46063 1/20 0.44
MAPK13 O15264 2/20 0.43
MAPK12 P53778 2/20 0.43
MAPK11 Q15759 2/20 0.43
MAPK14 Q16539 2/20 0.43
SLC6A2 P23975 1/20 0.43
SLC6A4 P31645 1/20 0.43
SLC6A3 Q01959 1/20 0.43
HPGD P15428 1/20 0.43
KDM4E B2RXH2 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15851058 0.84 KMT2A (0.54) KMT2AALDH1A1POLBMTNR1AMTNR1B
SCHEMBL9712425 0.79 KMT2A (0.49) KMT2AALDH1A1POLBMTNR1AMTNR1B
SCHEMBL3444937 0.78 KMT2A (0.72) KMT2AALDH1A1POLBMTNR1AMTNR1B
SCHEMBL195683 0.78 KMT2A (0.67) KMT2AALDH1A1POLBMTNR1AMTNR1B
SCHEMBL10727775 0.78 SLC6A2 (0.60) KMT2AALDH1A1POLBMTNR1AMTNR1B
SCHEMBL9712419 0.77 KMT2A (0.52) KMT2AALDH1A1CES2CES1RECQL
SCHEMBL3444657 0.77 KMT2A (0.56) KMT2AALDH1A1POLBMTNR1AMTNR1B
SCHEMBL8962328 0.77 CDC25B (0.77) KMT2AALDH1A1POLBMTNR1AMTNR1B
SCHEMBL8459090 0.77 RAB9A (0.53) KMT2ACES2CES1RECQLMAPK13
SCHEMBL1773780 0.77 CES2 (0.39) KMT2AALDH1A1POLBHSD17B10CES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5117057-A Insecticidal N' substituted-N-N'-disubstituted-hydrazines ROHM AND HAAS COMPANY (US) 1992-05-26 US disclosed