Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9713709 | 0.79 | TP53 (0.44) | PTGESALOX5PPARGL3MBTL1 | |
| Hydrochloric Acid SCHEMBL3102838 | 0.78 | FFAR1 (0.56) | S1PR1 | |
| SCHEMBL9713209 | 0.77 | KDM4E (0.46) | KDM4EALDH1A1MAPTS1PR1TDP1 | |
| SCHEMBL4657637 | 0.76 | FFAR1 (0.62) | S1PR1 | |
| Bromide SCHEMBL2292201 | 0.76 | TP53 (0.43) | PTGESALOX5PPARGL3MBTL1 | |
| Hydrochloric Acid SCHEMBL8680191 | 0.72 | PTGES2 (0.42) | KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL9063521 | 0.72 | TRAP1 (0.51) | KDM4EALDH1A1HTR2ATDP1 | |
| Hydrochloric Acid SCHEMBL5829422 | 0.71 | L3MBTL1 (0.47) | ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL16715459 | 0.71 | MAPT (0.48) | KDM4EALDH1A1MAPTS1PR1L3MBTL1 | |
| SCHEMBL30962112 | 0.71 | CHRNA7 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5140046-A | Slow reacting substance of anaphylaxis antagonists | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-08-18 | — | — | US | disclosed |
| US-5116853-A | SRS-Antagonist, Antiallergens | MASE TOSHIYASU (JP) | 1992-05-26 | — | — | US | disclosed |
| US-4994479-A | Antagonists of SRS-A(slow reacting substance of anaphylaxis); antiallergens, antiischemic agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-02-19 | — | — | US | disclosed |
| EP-0218728-A1 | PHENYLENE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1987-04-22 | — | — | EP | disclosed |
| WO-1986005779-A1 | PHENYLENE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1986-10-09 | — | — | WO | disclosed |