Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10569735 | 0.81 | GABRA1 (0.68) | ALDH1A1TDP1GPBAR1MAPK1GABRA1 | |
| SCHEMBL11733511 | 0.78 | ALDH1A1 (0.78) | ALDH1A1TDP1GPBAR1MAPK1GABRA1 | |
| SCHEMBL25135971 | 0.75 | ALDH1A1 (0.46) | ALDH1A1TDP1GPBAR1MAPK1GABRA1 | |
| SCHEMBL9714322 | 0.69 | ADA (0.48) | CES2CES1 | |
| SCHEMBL11483915 | 0.69 | ALDH1A1 (0.55) | ALDH1A1TDP1GPBAR1MAPK1GABRA1 | |
| SCHEMBL9714161 | 0.69 | CA5A (0.48) | ALDH1A1GPBAR1CYP11B1CYP11B2TGFBR1 | |
| SCHEMBL10959131 | 0.67 | CA5A (0.52) | ALDH1A1LMNASMN1; SMN2CES2CES1 | |
| SCHEMBL1081228 | 0.66 | ALDH1A1 (1.00) | ALDH1A1TDP1GPBAR1MAPK1GABRA1 | |
| SCHEMBL11726722 | 0.66 | ALDH1A1 (1.00) | ALDH1A1TDP1GPBAR1MAPK1GABRA1 | |
| SCHEMBL1081229 | 0.66 | ALDH1A1 (1.00) | ALDH1A1TDP1GPBAR1MAPK1GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0248414-B1 | ARALKYL IMIDAZOLE DERIVATIVES | CIBA-GEIGY AG (CH) | 1992-09-23 | — | — | EP | claimed |
| EP-0248414-A2 | Aralkyl imidazole derivatives | CIBA-GEIGY AG (CH) | 1987-12-09 | — | — | EP | claimed |
| EP-0248414-B1 | ARALKYL IMIDAZOLE DERIVATIVES | CIBA-GEIGY AG (CH) | 1992-09-23 | — | — | EP | disclosed |
| US-4851424-A | 1-Phenyl-lower alkyl-imidazole 4- or 5-carboxamide compounds which are useful in the treatment of epilepsy | CIBA-GEIGY CORPORATION (US) | 1989-07-25 | — | — | US | disclosed |
| EP-0248414-A2 | Aralkyl imidazole derivatives | CIBA-GEIGY AG (CH) | 1987-12-09 | — | — | EP | disclosed |