Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9714667 | 0.88 | SGMS2 (0.40) | SGMS2BCHEPTGESTAAR1MAOB | |
| Hydrochloric Acid SCHEMBL9714793 | 0.86 | CHRNA7 (0.40) | SIGMAR1SLC2A1 | |
| Hydrochloric Acid SCHEMBL9714808 | 0.82 | GUSB (0.39) | SGMS2 | |
| Hydrochloric Acid SCHEMBL9714652 | 0.81 | MEN1 (0.37) | SIGMAR1TAAR1MAOB | |
| Hydrochloric Acid SCHEMBL9714819 | 0.79 | SNCA (0.38) | SIGMAR1CTSBTAAR1MAOB | |
| Bromide SCHEMBL9442294 | 0.77 | KCNA3 (0.50) | SIGMAR1SLC2A1 | |
| Bromide SCHEMBL6416452 | 0.77 | KDM4E (0.43) | SIGMAR1SLC2A1TSHRTAAR1MAOB | |
| SCHEMBL9714712 | 0.76 | TSHR (0.36) | SIGMAR1SLC2A1TSHRMAPK1TDP1 | |
| Hydrochloric Acid SCHEMBL5248234 | 0.74 | TAAR1 (0.56) | SIGMAR1TAAR1MAOB | |
| Hydrochloric Acid SCHEMBL9714833 | 0.73 | SNCA (0.45) | SIGMAR1TSHRMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166210-A | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5028615-A | Treatment of hypersensitivity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-07-02 | — | — | US | disclosed |