Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9714665 | 0.89 | SGMS2 (0.39) | TSHRTDP1SGMS2BCHEALDH1A1 | |
| SCHEMBL9714791 | 0.87 | LTA4H (0.36) | MAPK1L3MBTL1TDP1SIGMAR1SLC2A1 | |
| SCHEMBL9714805 | 0.83 | GUSB (0.38) | SGMS2 | |
| SCHEMBL9714646 | 0.82 | MEN1 (0.35) | TSHRTDP1OPRM1OPRD1KDM4E | |
| SCHEMBL9714816 | 0.79 | SLC6A2 (0.34) | TSHRTDP1SIGMAR1CTSBSLC6A2 | |
| Hydrochloric Acid SCHEMBL9714716 | 0.76 | SIGMAR1 (0.39) | TSHRMAPK1L3MBTL1TDP1SIGMAR1 | |
| SCHEMBL28703047 | 0.76 | BCHE (0.54) | L3MBTL1BCHEALDH1A1MAOBKDM4E | |
| SCHEMBL29463763 | 0.76 | BCHE (0.54) | L3MBTL1BCHEALDH1A1MAOBKDM4E | |
| SCHEMBL9714829 | 0.75 | CYP3A4 (0.34) | TSHRTDP1ALDH1A1KDM4EMEN1 | |
| SCHEMBL5973608 | 0.74 | SIGMAR1 (0.53) | SIGMAR1ALDH1A1SMN1; SMN2CHRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166210-A | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5028615-A | Treatment of hypersensitivity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-07-02 | — | — | US | disclosed |