Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 2/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.31 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9714580 | 0.78 | MEN1 (0.35) | SNCAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL2247673 | 0.77 | TSHR (0.41) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL2247670 | 0.77 | TSHR (0.41) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL9714753 | 0.75 | NLRP3 (0.33) | SNCANLRP3MEN1KMT2AAPP | |
| Hydrochloric Acid SCHEMBL9714709 | 0.75 | SNCA (0.36) | SNCAAPPALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL9714784 | 0.74 | MEN1 (0.62) | SNCAMEN1KMT2AAPPCTSS | |
| SCHEMBL12231441 | 0.74 | KMT2A (0.41) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL12231439 | 0.74 | KMT2A (0.41) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL9714808 | 0.71 | GUSB (0.39) | — | |
| Hydrochloric Acid SCHEMBL9714813 | 0.70 | ENPP2 (0.44) | SNCAMEN1KMT2AAPPKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166210-A | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5028615-A | Treatment of hypersensitivity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-07-02 | — | — | US | disclosed |