Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.31 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9714580 | 0.86 | MEN1 (0.35) | SNCAMAOBMAOAKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL9714744 | 0.83 | MAOB (0.38) | SNCAMAOBMAOAHIF1AAPP | |
| Hydrochloric Acid SCHEMBL9714813 | 0.76 | ENPP2 (0.44) | SNCAMAOBKDM4EHIF1AAPP | |
| Hydrochloric Acid SCHEMBL4614799 | 0.76 | ALDH1A1 (0.42) | SNCAMAOBMAOAALDH1A1CHRNA7 | |
| SCHEMBL28373742 | 0.76 | MMP3 (0.47) | MAOBMAOAKDM4ECYP4F2CYP4A11 | |
| Hydrochloric Acid SCHEMBL5149449 | 0.75 | SNCA (0.52) | SNCAMAOAALDH1A1HIF1AAPP | |
| Hydrochloric Acid SCHEMBL9714757 | 0.75 | SNCA (0.34) | SNCAKDM4EALDH1A1APP | |
| Hydrochloric Acid SCHEMBL9714784 | 0.74 | MEN1 (0.62) | SNCAMAOBMAOAHIF1AAPP | |
| Hydrochloric Acid SCHEMBL9714843 | 0.73 | SNCA (0.36) | SNCAMAOBHIF1AAPP | |
| Hydrochloric Acid SCHEMBL9714743 | 0.73 | FOLH1 (0.48) | SNCAMAOBMAOAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166210-A | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5028615-A | Treatment of hypersensitivity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-07-02 | — | — | US | disclosed |