Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ILK | Q13418 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.42 |
| ▸ | PRKDC | P78527 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9714985 | 0.86 | ABL1 (0.43) | MAPK1NPSR1RPS6KA3GAASMN1; SMN2 | |
| SCHEMBL11242632 | 0.82 | KDM4E (0.50) | NPSR1GAASMN1; SMN2KDM4ENPC1 | |
| SCHEMBL9714918 | 0.82 | LMNA (0.54) | MAPK1NPSR1GAASMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL9715094 | 0.81 | LMNA (0.53) | MAPK1NPSR1GAASMN1; SMN2KDM4E | |
| SCHEMBL9714922 | 0.80 | ALDH1A1 (0.44) | MAPK1NPSR1RPS6KA3SMN1; SMN2KDM4E | |
| SCHEMBL9714945 | 0.78 | HSD17B10 (0.46) | MAPK1NPSR1GAASMN1; SMN2KDM4E | |
| SCHEMBL2949076 | 0.71 | KDM4E (0.68) | MAPK1NPSR1RPS6KA3GAASMN1; SMN2 | |
| SCHEMBL5820038 | 0.70 | MAPK1 (1.00) | MAPK1NPSR1RPS6KA3GAASMN1; SMN2 | |
| SCHEMBL2870468 | 0.68 | GAA (0.68) | MAPK1NPSR1RPS6KA3GAASMN1; SMN2 | |
| SCHEMBL2875437 | 0.68 | MAPK1 (0.63) | MAPK1NPSR1RPS6KA3GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992018484-A1 | 3-AMINO-5-ARYLPYRAZOLE-4-ACETIC ACID DERIVATIVES EXHIBITING THERAPEUTIC EFFECTS | A.H. ROBINS COMPANY, INCORPORATED (US) | 1992-10-29 | — | — | WO | claimed |
| US-5057534-A | Anxiolytic, anticonfulsant and muscle relaxants | A. H. ROBINS COMPANY INCORPORATED (US) | 1991-10-15 | — | — | US | claimed |
| WO-1992018484-A1 | 3-AMINO-5-ARYLPYRAZOLE-4-ACETIC ACID DERIVATIVES EXHIBITING THERAPEUTIC EFFECTS | A.H. ROBINS COMPANY, INCORPORATED (US) | 1992-10-29 | — | — | WO | disclosed |
| US-5057534-A | Anxiolytic, anticonfulsant and muscle relaxants | A. H. ROBINS COMPANY INCORPORATED (US) | 1991-10-15 | — | — | US | disclosed |