SCHEMBL9715740

SCHEMBL9715740

C=C(c1ccc(C)cc1)c1ccc(C(C)C(=O)O)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 8/20 0.50
PTGS1 P23219 5/20 0.47
CYP2C9 P11712 4/20 0.47
LMNA P02545 4/20 0.47
AKR1C3 P42330 3/20 0.47
CXCR1 P25024 2/20 0.47
CXCR2 P25025 2/20 0.47
AKR1C2 P52895 2/20 0.47
ALB P02768 1/20 0.47
ESR1 P03372 1/20 0.47
ALOX5 P09917 1/20 0.47
RARB P10826 1/20 0.47
ADRB3 P13945 1/20 0.47
NFKB1 P19838 1/20 0.47
HTR2A P28223 1/20 0.47
NR1I3 Q14994 1/20 0.47
SLC22A6 Q4U2R8 1/20 0.47
CXCL8 P10145 1/20 0.47
TSHR P16473 1/20 0.47
BLM P54132 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9715764 0.87 PTGS2 (0.61) PTGS2PTGS1CYP2C9LMNAAKR1C3
SCHEMBL349312 0.87 PTGS2 (0.63) PTGS2PTGS1CYP2C9LMNAAKR1C3
SCHEMBL3093415 0.87 PTGS2 (0.63) PTGS2PTGS1CYP2C9LMNAAKR1C3
SCHEMBL597882 0.87 PTGS2 (0.63) PTGS2PTGS1CYP2C9LMNAAKR1C3
SCHEMBL18205083 0.85 PTGS2 (0.61) PTGS2PTGS1CYP2C9LMNAAKR1C3
Water SCHEMBL30850045 0.85 PTGS2 (0.61) PTGS2PTGS1CYP2C9LMNAAKR1C3
Hydrochloric Acid SCHEMBL5846561 0.85 PTGS2 (0.61) PTGS2PTGS1CYP2C9LMNAAKR1C3
SCHEMBL10415941 0.83 PTGS2 (0.55) PTGS2PTGS1CYP2C9LMNAAKR1C3
SCHEMBL22228509 0.81 PTGS2 (0.68) PTGS2PTGS1CYP2C9LMNAAKR1C3
Formic Acid SCHEMBL30236894 0.79 PTGS2 (0.55) PTGS2PTGS1CYP2C9LMNAAKR1C3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0304495-B1 PROCESS FOR SELECTIVELY MONOHYDROESTERIFYING DIOLEFIN NIPPON PETROCHEMICALS COMPANY, LIMITED (JP) 1992-05-27 EP disclosed
US-4908473-A Reacting a (1-arylethenyl)vinylbenzene with carbon monoxide and water or alcohol in the presence of carbonylation catalyst NIPPON PETROCHEMICALS COMPANY, LIMITED (JP) 1990-03-13 US disclosed
EP-0304495-A1 PROCESS FOR SELECTIVELY MONOHYDROESTERIFYING DIOLEFIN NIPPON PETROCHEMICALS COMPANY, LIMITED (JP) 1989-03-01 EP disclosed