SCHEMBL9715968

SCHEMBL9715968

CCOc1ccc2c(c1)oc(=O)n2CC#CI

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.47
CA1 P00915 1/20 0.47
CYP1A2 P05177 1/20 0.47
CA4 P22748 1/20 0.47
CA6 P23280 1/20 0.47
CA5A P35218 1/20 0.47
CA7 P43166 1/20 0.47
CA9 Q16790 1/20 0.47
CA14 Q9ULX7 1/20 0.47
CA5B Q9Y2D0 1/20 0.47
HPGD P15428 4/20 0.42
TSHR P16473 1/20 0.42
MET P08581 3/20 0.42
LMNA P02545 3/20 0.42
PKM P14618 1/20 0.42
HTT P42858 1/20 0.42
ALDH1A1 P00352 3/20 0.41
KDM4E B2RXH2 2/20 0.41
GLA P06280 1/20 0.41
MEN1 O00255 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9715984 0.90 ALDH1A1 (0.48) CA12CA1CYP1A2CA4CA6
SCHEMBL9716010 0.87 MET (0.51) CA12CA1CA4CA6CA5A
SCHEMBL9716052 0.80 MIF (0.57) TSHRMETLMNAHTTALDH1A1
SCHEMBL9716002 0.78 MIF (0.44) METKMT2A
SCHEMBL9715990 0.78 NPC1 (0.57) HPGDTSHRLMNAPKMHTT
SCHEMBL536309 0.78 TDP1 (0.47) HPGDLMNAALDH1A1MAPTKMT2A
SCHEMBL9715940 0.77 KMO (0.58) HPGDMETALDH1A1MAPTTP53
SCHEMBL9715963 0.74 KMO (0.46) CYP1A2HPGDTSHRLMNAKDM4E
SCHEMBL9716054 0.74 MIF (0.46) LMNAALDH1A1MEN1MAPTKMT2A
SCHEMBL536696 0.74 MAPK1 (0.62) HPGDTSHRLMNAALDH1A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5102898-A Halosubstituted alkyne group; fungicides ROHM AND HAAS COMPANY (US) 1992-04-07 US disclosed