SCHEMBL9715971

SCHEMBL9715971

COc1cccc2oc(=O)n(CC#CI)c12

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.41
MIF P14174 4/20 0.40
CD74 P04233 2/20 0.40
HTR1A P08908 4/20 0.38
HTR7 P34969 4/20 0.38
POLB P06746 2/20 0.38
CBX7 O95931 1/20 0.38
CDYL2 Q8N8U2 1/20 0.38
CDYL Q9Y232 1/20 0.38
CDY1; CDY1B Q9Y6F8 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
MAOA P21397 1/20 0.37
NQO1 P15559 1/20 0.36
HPGD P15428 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9716043 0.87 CYP2A6 (0.46) CYP2A6POLBTDP1HPGD
SCHEMBL9715954 0.82 POLB (0.39) MIFCD74POLBHPGD
SCHEMBL9715930 0.80 IDO1 (0.37) MIFCD74POLBHPGD
SCHEMBL9715956 0.80 IDO1 (0.38) MIFPOLBHPGD
SCHEMBL9715982 0.80 ALDH1A1 (0.43) MIFPOLBHPGD
SCHEMBL9715962 0.79 GAA (0.39) CYP2A6MIFCD74HTR1AHTR7
SCHEMBL9715979 0.76 KMO (0.46) MIFCD74CBX7CDYL2CDYL
SCHEMBL9715967 0.75 MEN1 (0.36) MIFTDP1HPGD
SCHEMBL536696 0.73 MAPK1 (0.62) MIFPOLBHPGD
SCHEMBL9715940 0.71 KMO (0.58) MIFCD74POLBCBX7CDYL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5102898-A Halosubstituted alkyne group; fungicides ROHM AND HAAS COMPANY (US) 1992-04-07 US disclosed