SCHEMBL9715974

SCHEMBL9715974

O=c1oc2cc([N+](=O)[O-])ccc2n1CC#CI

nearest known ligand 0.50

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.47
ASAH1 Q13510 2/20 0.41
CYP1A2 P05177 1/20 0.41
CDYL2 Q8N8U2 1/20 0.39
CDYL Q9Y232 1/20 0.39
CDY1; CDY1B Q9Y6F8 1/20 0.39
APEX1 P27695 1/20 0.38
MAPT P10636 3/20 0.37
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
LMNA P02545 1/20 0.36
MIF P14174 1/20 0.35
NPC1 O15118 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9715932 0.90 IDO1 (0.59) IDO1ASAH1CYP1A2CDYL2CDYL
SCHEMBL3043360 0.80 CYP1A2 (0.60) IDO1ASAH1CYP1A2CDYL2CDYL
SCHEMBL536309 0.79 TDP1 (0.47) IDO1MAPTKMT2ALMNAMIF
SCHEMBL9716002 0.79 MIF (0.44) IDO1ASAH1KMT2AMIFNPC1
SCHEMBL9715990 0.79 NPC1 (0.57) ASAH1CDYL2CDYLCDY1; CDY1BAPEX1
SCHEMBL9716052 0.79 MIF (0.57) MEN1KMT2ALMNAMIF
SCHEMBL9716010 0.75 MET (0.51) CDYL2CDYLCDY1; CDY1BMAPTKMT2A
SCHEMBL9715963 0.75 KMO (0.46) ASAH1CYP1A2APEX1MAPTMEN1
SCHEMBL30806471 0.75 IDO1 (0.64) IDO1ASAH1MIFNPC1
SCHEMBL2060899 0.75 IDO1 (0.51) IDO1ASAH1CYP1A2APEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5102898-A Halosubstituted alkyne group; fungicides ROHM AND HAAS COMPANY (US) 1992-04-07 US disclosed