Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 3/20 | 0.84 |
| ▸ | GABRD | O14764 | 3/20 | 0.84 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.84 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.84 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.84 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.84 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.84 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.84 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.84 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.84 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.84 |
| ▸ | GABRE | P78334 | 3/20 | 0.84 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.84 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.84 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.84 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.84 |
| ▸ | CDK1 | P06493 | 7/20 | 0.61 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.61 |
| ▸ | ACHE | P22303 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367741 | 0.91 | GABRP (1.00) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL27974348 | 0.88 | MAPT (0.77) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL21318438 | 0.85 | GABRP (0.65) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL29149073 | 0.82 | GABRP (0.70) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL21145438 | 0.79 | CDK1 (0.71) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL27939886 | 0.79 | ALDH1A1 (0.76) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL973228 | 0.79 | CREB1 (0.65) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL27779531 | 0.77 | GABRP (0.55) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6725127 | 0.77 | GABRP (0.62) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL10013320 | 0.77 | ABCB1 (0.64) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7875650-B2 | Baicalein analogs; enhances bioavailability of active compounds, especially orally administered compounds, by inhibition of P-glycoprotein 170 (P-gp 170) and/or CYP450 enzyme; 6-Acetoxy-5,7-dihydroxyflavone | YALE UNIVERSITY (US) | 2011-01-25 | — | — | US | disclosed |
| US-20070161605-A1 | Compounds and methods to increase anti-p-glycoprotein activity of baicalein by alkylation on the a ring | YALE UNIVERSITY (US) | 2007-07-12 | — | — | US | disclosed |
| WO-2005075449-A1 | COMPOUNDS AND METHODS TO INCREASE ANTI-P-GLYCOPROTEIN ACTIVITY OF BAICALEIN BY ALKYLATION ON THE A RING | YALE UNIVERSITY (US) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161605-A1 | Compounds and methods to increase anti-p-glycoprotein activity of baicalein by alkylation on the a ring | ABCB1, ABCB11, ABCG2 | GABRP 373/4885GABRD 2715/4885GABRA1 1308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.