SCHEMBL9717515

SCHEMBL9717515

O=Cc1ccc(OCCCC(=O)O)c(Cl)c1Cl

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 2/20 0.48
RAB9A P51151 2/20 0.46
TSHR P16473 3/20 0.44
PTGDR2 Q9Y5Y4 3/20 0.44
MAPT P10636 1/20 0.40
HPGD P15428 5/20 0.40
PPARG P37231 2/20 0.40
ALDH1A1 P00352 2/20 0.40
KDM4E B2RXH2 1/20 0.40
CASP1 P29466 1/20 0.40
CASP7 P55210 1/20 0.40
NCOA2 Q15596 1/20 0.40
NCOA1 Q15788 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
HSD17B10 Q99714 1/20 0.40
NCOA3 Q9Y6Q9 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.39
HTT P42858 1/20 0.39
PPARA Q07869 1/20 0.39
NPC1 O15118 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9717536 0.95 FFAR4 (0.44) FFAR4RAB9ATSHRPTGDR2HPGD
SCHEMBL9717537 0.94 FFAR4 (0.44) FFAR4RAB9ATSHRPTGDR2HPGD
SCHEMBL9717613 0.92 PTGDR2 (0.44) FFAR4RAB9ATSHRPTGDR2MAPT
SCHEMBL6313773 0.87 PTGDR2 (0.53) FFAR4RAB9ATSHRPTGDR2HPGD
SCHEMBL19025056 0.83 CYSLTR2 (0.43) FFAR4RAB9ATSHRPTGDR2PPARG
SCHEMBL11684698 0.81 ALDH1A1 (0.43) TSHRPTGDR2MAPTHPGDPPARG
SCHEMBL9717525 0.78 FFAR4 (0.41) FFAR4RAB9ATSHRPTGDR2MAPT
SCHEMBL9717532 0.78 FFAR4 (0.41) FFAR4RAB9ATSHRPTGDR2MAPT
SCHEMBL9717519 0.78 FFAR4 (0.41) FFAR4RAB9ATSHRPTGDR2MAPT
SCHEMBL5304037 0.78 PTGDR2 (0.70) FFAR4TSHRPTGDR2MAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0240256-B1 COMPOUNDS USEFUL IN TREATING SICKLE CELL ANEMIA MERCK & CO. INC. (US) 1992-04-29 EP disclosed
US-4751244-A NITROALKENYL CARBOXYLIC ACIDS MERCK & CO., INC. (US) 1988-06-14 US disclosed
EP-0240256-A2 Compounds useful in treating sickle cell anemia MERCK & CO. INC. (US) 1987-10-07 EP disclosed