Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.50 |
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.50 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.50 |
| ▸ | SLC18A2 known ✓ | Q05940 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30934 | 0.86 | TRPA1 (0.77) | TRPA1CYP2D6TAAR1SLC6A2SIGMAR1 | |
| SCHEMBL17210746 | 0.84 | TRPA1 (0.55) | TRPA1CYP2D6TAAR1SLC6A2SIGMAR1 | |
| SCHEMBL1140503 | 0.84 | TRPA1 (0.74) | TRPA1CYP2D6TAAR1SLC6A2SIGMAR1 | |
| Water SCHEMBL3896311 | 0.84 | TRPA1 (0.74) | TRPA1CYP2D6TAAR1SLC6A2SIGMAR1 | |
| Amphetamine SCHEMBL8025793 | 0.83 | TAAR1 (0.76) | CYP2D6TAAR1SLC6A2SIGMAR1MAOA | |
| Amphetamine SCHEMBL4016537 | 0.83 | TAAR1 (0.76) | CYP2D6TAAR1SLC6A2SIGMAR1MAOA | |
| Dextroamphetamine SCHEMBL18948 | 0.83 | TAAR1 (0.76) | CYP2D6TAAR1SLC6A2SIGMAR1MAOA | |
| Amphetamine SCHEMBL41203 | 0.83 | TAAR1 (0.76) | CYP2D6TAAR1SLC6A2SIGMAR1MAOA | |
| Amphetamine SCHEMBL6465998 | 0.83 | TAAR1 (0.76) | CYP2D6TAAR1SLC6A2SIGMAR1MAOA | |
| Dextroamphetamine SCHEMBL7204032 | 0.83 | TAAR1 (0.76) | CYP2D6TAAR1SLC6A2SIGMAR1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0324227-B1 | A COMPOSITION OF MATTER FOR INCREASING INTRACELLULAR ATP LEVELS AND PHYSICAL PERFORMANCE LEVELS AND FOR INCREASING THE RATE OF WOUND REPAIR | Roncari, Raymond A. (US) | 1992-06-24 | — | — | EP | claimed |
| US-4923851-A | AMINO ACIDS, CHOLINE CHLORIDE AND/OR INOSITOL, RIBOSE, ELECTROLYTE, ADENOSINE TRIPHOSPHATE | Roncari, Raymond A. (US) | 1990-05-08 | — | — | US | claimed |
| US-4871718-A | AMINO ACIDS, METABOLITES, ELECTROLYTES, PENTOSE SUGAR | Roncari, Raymond A. (US) | 1989-10-03 | — | — | US | claimed |
| EP-0324227-A1 | A composition of matter for increasing intracellular atp levels and physical performance levels and for increasing the rate of wound repair | Roncari, Raymond A. (US) | 1989-07-19 | — | — | EP | claimed |
| EP-0324227-B1 | A COMPOSITION OF MATTER FOR INCREASING INTRACELLULAR ATP LEVELS AND PHYSICAL PERFORMANCE LEVELS AND FOR INCREASING THE RATE OF WOUND REPAIR | Roncari, Raymond A. (US) | 1992-06-24 | — | — | EP | disclosed |
| EP-0324227-A1 | A composition of matter for increasing intracellular atp levels and physical performance levels and for increasing the rate of wound repair | Roncari, Raymond A. (US) | 1989-07-19 | — | — | EP | disclosed |