Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9660574 | 0.85 | ALDH1A1 (0.68) | KMT2AAKR1C3ALDH1A1MEN1MAPT | |
| SCHEMBL11575084 | 0.81 | TBXA2R (0.58) | KMT2AAKR1C3ALDH1A1MEN1MAPT | |
| SCHEMBL16922187 | 0.76 | KMT2A (1.00) | KMT2AL3MBTL1ALDH1A1MEN1LMNA | |
| SCHEMBL822930 | 0.76 | KMT2A (1.00) | KMT2AL3MBTL1ALDH1A1MEN1LMNA | |
| Succinic Acid SCHEMBL8467793 | 0.76 | KMT2A (1.00) | KMT2AL3MBTL1ALDH1A1MEN1LMNA | |
| SCHEMBL10867378 | 0.75 | ALDH1A1 (0.56) | L3MBTL1ALDH1A1MAPTLMNANPC1 | |
| SCHEMBL9659259 | 0.75 | ALDH1A1 (0.71) | L3MBTL1AKR1C3ALDH1A1MAPTTBXA2R | |
| SCHEMBL10865713 | 0.74 | L3MBTL1 (0.66) | KMT2AL3MBTL1ALDH1A1MAPTLMNA | |
| SCHEMBL10463031 | 0.73 | ALDH1A1 (0.64) | KMT2AL3MBTL1ALDH1A1MEN1MAPT | |
| SCHEMBL9130450 | 0.73 | TBXA2R (0.53) | KMT2AL3MBTL1AKR1C3ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260527-B1 | SYNERGETIC COMBINATION COMPRISING A PHOSPHODIESTERASE INHIBITOR AND A THROMBOXAN-A2-ANTAGONIST, AND THEIR USE OR MANUFACTURE | Dr. Karl Thomae GmbH (DE) | 1992-04-01 | — | — | EP | disclosed |
| EP-0260527-A2 | Synergetic combination comprising a phosphodiesterase inhibitor and a thromboxan-A2-antagonist, and their use or manufacture | Dr. Karl Thomae GmbH (DE) | 1988-03-23 | — | — | EP | disclosed |
| EP-0194548-A2 | Sulfonylaminoethyl compounds, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1986-09-17 | — | — | EP | disclosed |