Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | S1PR2 | O95136 | 6/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.43 |
| ▸ | LPAR2 | Q9HBW0 | 5/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27936092 | 0.85 | CA1 (0.47) | ALDH1A1SMN1; SMN2HPGDHTTMAPT | |
| SCHEMBL9718999 | 0.81 | HSD17B10 (0.65) | ALDH1A1SMN1; SMN2MEN1HPGDKMT2A | |
| SCHEMBL9719016 | 0.81 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2MEN1HPGDKMT2A | |
| SCHEMBL1020821 | 0.76 | PTGS2 (0.57) | MAPT | |
| SCHEMBL15506125 | 0.74 | PIK3CD (0.37) | ALDH1A1HTTMAPTRAB9ALMNA | |
| SCHEMBL6897446 | 0.74 | ALOX5 (0.53) | ALDH1A1MEN1KMT2AHTTMAPT | |
| SCHEMBL7281740 | 0.72 | DHFR (0.49) | ALDH1A1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL4291750 | 0.71 | HSD17B10 (0.60) | ALDH1A1SMN1; SMN2MEN1HPGDKMT2A | |
| SCHEMBL4295742 | 0.71 | S1PR2 (0.57) | ALDH1A1SMN1; SMN2MEN1HPGDKMT2A | |
| SCHEMBL19818498 | 0.71 | PTGS2 (0.67) | ALDH1A1SMN1; SMN2MEN1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132463-A | Cardiovascular, skin, kidney, respiratory system, and gastrointestinal disorders | MERCK & CO., INC. (US) | 1992-07-21 | — | — | US | disclosed |
| EP-0257921-B1 | NEW 1,3-DIARYL CYCLOPENTANES AND DERIVATIVES THEREOF AS PAF ANTAGONISTS | MERCK & CO. INC. (US) | 1992-04-15 | — | — | EP | disclosed |
| US-5047420-A | Platelet activating factor | MERCK & CO., INC. (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0257921-A2 | New 1,3-diaryl cyclopentanes and derivatives thereof as paf antagonists | MERCK & CO. INC. (US) | 1988-03-02 | — | — | EP | disclosed |