Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL27868428 | 0.91 | HTT (0.40) | ALDH1A1TP53HTTNPC1GAA | |
| Monomethyl Fumarate SCHEMBL8850796 | 0.90 | HCAR2 (0.53) | ALDH1A1HCAR2POLBATMHTT | |
| SCHEMBL372980 | 0.88 | ALDH1A1 (0.46) | ALDH1A1TSHRATMTHRBHSD17B10 | |
| SCHEMBL25278 | 0.88 | — | — | |
| SCHEMBL342182 | 0.88 | ALDH1A1 (0.46) | ALDH1A1TSHRATMTHRBHSD17B10 | |
| SCHEMBL6674567 | 0.84 | ALDH1A1 (0.39) | ALDH1A1TSHRTHRB | |
| Crotonic Acid SCHEMBL27868390 | 0.83 | EPHX1 (0.36) | ALDH1A1HTTNPC1GAASMN1; SMN2 | |
| SCHEMBL295003 | 0.82 | TSHR (0.36) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL91312 | 0.82 | ALDH1A1 (0.41) | ALDH1A1TSHRTHRBALOX15HSD17B10 | |
| SCHEMBL9972479 | 0.82 | ALDH1A1 (0.41) | ALDH1A1TSHRTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5089548-A | Ethylene-acrylic acid copolymer and polyether; acid-base indicator; diapers | H. B. FULLER COMPANY (US) | 1992-02-18 | — | — | US | disclosed |
| US-5035691-A | Diapers | H. B. FULLER LICENSING & FINANCING INC. (US) | 1991-07-30 | — | — | US | disclosed |