Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1955524 | 0.76 | IDO1 (0.46) | IDO1KDM4ERAB9ASMN1; SMN2MAPT | |
| SCHEMBL9156403 | 0.76 | NAAA (0.50) | IDO1MAPTMEN1HTTKMT2A | |
| SCHEMBL7398389 | 0.76 | SMN1; SMN2 (0.44) | KDM4ESMN1; SMN2MEN1KMT2ACA1 | |
| SCHEMBL9719833 | 0.76 | ALDH1A1 (0.55) | KDM4ERAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL1161081 | 0.76 | IDO1 (0.49) | IDO1KDM4ESMN1; SMN2MAPTMAPK1 | |
| SCHEMBL12599071 | 0.74 | IDO1 (0.81) | IDO1MAPTMAPK1MEN1HTT | |
| SCHEMBL30824997 | 0.74 | IDO1 (0.81) | IDO1MAPTMAPK1MEN1HTT | |
| SCHEMBL9363845 | 0.74 | TLR8 (0.45) | IDO1KDM4ERAB9ASMN1; SMN2MAPT | |
| SCHEMBL8176117 | 0.73 | NR4A2 (0.54) | KDM4ERAB9ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL17732422 | 0.72 | CYP19A1 (0.73) | IDO1KDM4ERAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157039-A | Lipoxygenase inhibitors | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-10-20 | — | — | US | disclosed |
| US-5109009-A | QUINOLINE AND PYRIDINE COMPOUNDS AND INHIBITION OF 5-LIPOXYGENASES THEREWITH | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-04-28 | — | — | US | disclosed |
| US-4826987-A | Pyridyl and quinoline derivatives | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1989-05-02 | — | — | US | disclosed |