Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 2/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9719877 | 0.77 | CYP1A2 (0.53) | ALDH1A1CYP1A2KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL9719828 | 0.76 | IDO1 (0.45) | ALDH1A1CYP3A4POLBL3MBTL1UTS2R | |
| SCHEMBL14141593 | 0.75 | LMNA (0.55) | ALDH1A1L3MBTL1CHRM2GAAMAPK1 | |
| SCHEMBL9023989 | 0.74 | ALOX5 (0.42) | ALDH1A1CYP1A2CYP3A4CYP2C19CHRM2 | |
| SCHEMBL6173269 | 0.74 | CHRM2 (0.70) | ALDH1A1CYP1A2CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL8519906 | 0.73 | ALDH1A1 (0.45) | ALDH1A1CYP3A4L3MBTL1CHRM2GBA1 | |
| SCHEMBL28033918 | 0.73 | GAA (0.56) | ALDH1A1POLBL3MBTL1CHRM2UTS2R | |
| SCHEMBL27873244 | 0.72 | LMNA (0.43) | ALDH1A1CYP1A2CYP3A4CYP2C19POLB | |
| SCHEMBL14339474 | 0.71 | KDM4E (0.50) | ALDH1A1CYP1A2CYP3A4CYP2C19POLB | |
| SCHEMBL8176117 | 0.70 | NR4A2 (0.54) | CYP1A2CYP3A4CYP2C19L3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157039-A | Lipoxygenase inhibitors | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-10-20 | — | — | US | disclosed |
| US-5109009-A | QUINOLINE AND PYRIDINE COMPOUNDS AND INHIBITION OF 5-LIPOXYGENASES THEREWITH | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-04-28 | — | — | US | disclosed |
| US-4826987-A | Pyridyl and quinoline derivatives | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1989-05-02 | — | — | US | disclosed |