Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 4/20 | 0.44 |
| ▸ | CCR2 | P41597 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9719793 | 0.81 | CCR2 (0.43) | METAP2CCR2MAPTNPC1RAB9A | |
| SCHEMBL9719813 | 0.79 | SYK (0.52) | CCR2MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6979593 | 0.74 | ERBB2 (0.59) | — | |
| SCHEMBL9719846 | 0.74 | CCR2 (0.41) | METAP2CCR2MAPTNPC1RAB9A | |
| SCHEMBL9719788 | 0.73 | SYK (0.46) | CCR2MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9719867 | 0.71 | MAPT (0.40) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL27945846 | 0.71 | CYP1A2 (0.59) | METAP2MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11177471 | 0.68 | GRM5 (0.50) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL5658228 | 0.68 | CYP1A2 (0.52) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9719840 | 0.67 | CYP1A2 (0.48) | METAP2MAPTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157039-A | Lipoxygenase inhibitors | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-10-20 | — | — | US | disclosed |
| US-5109009-A | QUINOLINE AND PYRIDINE COMPOUNDS AND INHIBITION OF 5-LIPOXYGENASES THEREWITH | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-04-28 | — | — | US | disclosed |
| US-4826987-A | Pyridyl and quinoline derivatives | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1989-05-02 | — | — | US | disclosed |