Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 9/20 | 0.41 |
| ▸ | RAB9A | P51151 | 9/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9719793 | 0.87 | CCR2 (0.43) | CCR2NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL9719788 | 0.77 | SYK (0.46) | CCR2NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL9719813 | 0.74 | SYK (0.52) | CCR2NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL9719845 | 0.74 | METAP2 (0.44) | CCR2NPC1RAB9ASMN1; SMN2MAPT | |
| Bromide SCHEMBL10628480 | 0.67 | ALDH1A1 (0.46) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL11177471 | 0.66 | GRM5 (0.50) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL27945846 | 0.66 | CYP1A2 (0.59) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL5658228 | 0.66 | CYP1A2 (0.52) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL9719840 | 0.65 | CYP1A2 (0.48) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL9719871 | 0.65 | DAO (0.41) | CCR2NPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157039-A | Lipoxygenase inhibitors | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-10-20 | — | — | US | disclosed |
| US-5109009-A | QUINOLINE AND PYRIDINE COMPOUNDS AND INHIBITION OF 5-LIPOXYGENASES THEREWITH | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-04-28 | — | — | US | disclosed |
| US-4826987-A | Pyridyl and quinoline derivatives | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1989-05-02 | — | — | US | disclosed |