Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9719802 | 0.80 | SYK (0.50) | MAPTALDH1A1KMT2AHPGDLMNA | |
| SCHEMBL6979593 | 0.72 | ERBB2 (0.59) | GAAEGFRERBB2STK4STK3 | |
| SCHEMBL9719845 | 0.71 | METAP2 (0.44) | MAPTALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL11263547 | 0.70 | HRH1 (0.42) | MAPTALDH1A1LMNAHRH3TAAR1 | |
| SCHEMBL11186796 | 0.70 | ATM (0.43) | MAPTALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL11188068 | 0.67 | NPC1 (0.46) | MAPTALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL11253725 | 0.66 | MAOA (0.43) | MAPTALDH1A1KMT2AHTTLMNA | |
| Hydrochloric Acid SCHEMBL9756590 | 0.66 | HRH1 (0.42) | MAPTALDH1A1KMT2ALMNAHRH3 | |
| SCHEMBL4612152 | 0.65 | HRH3 (0.46) | MAPTALDH1A1KMT2ALMNAHRH3 | |
| SCHEMBL28140567 | 0.65 | HRH3 (0.46) | MAPTALDH1A1KMT2ALMNAHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157039-A | Lipoxygenase inhibitors | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-10-20 | — | — | US | disclosed |
| US-5109009-A | QUINOLINE AND PYRIDINE COMPOUNDS AND INHIBITION OF 5-LIPOXYGENASES THEREWITH | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-04-28 | — | — | US | disclosed |
| US-4826987-A | Pyridyl and quinoline derivatives | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1989-05-02 | — | — | US | disclosed |