Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9719813 | 0.82 | SYK (0.52) | SYKSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL9719793 | 0.79 | CCR2 (0.43) | SYKSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL9719846 | 0.77 | CCR2 (0.41) | SYKSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL9719840 | 0.76 | CYP1A2 (0.48) | SYKSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL9719845 | 0.73 | METAP2 (0.44) | SMN1; SMN2NPC1RAB9AMAPTKDM4E | |
| SCHEMBL11177471 | 0.71 | GRM5 (0.50) | SYKSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL5658228 | 0.71 | CYP1A2 (0.52) | SYKSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL6640022 | 0.70 | RAB9A (0.49) | SMN1; SMN2NPC1RAB9AMAPTKDM4E | |
| SCHEMBL9756602 | 0.69 | RAB9A (0.60) | SMN1; SMN2NPC1RAB9AMAPTKDM4E | |
| SCHEMBL3388873 | 0.68 | L3MBTL1 (0.54) | SMN1; SMN2NPC1RAB9AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157039-A | Lipoxygenase inhibitors | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-10-20 | — | — | US | disclosed |
| US-5109009-A | QUINOLINE AND PYRIDINE COMPOUNDS AND INHIBITION OF 5-LIPOXYGENASES THEREWITH | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-04-28 | — | — | US | disclosed |
| US-4826987-A | Pyridyl and quinoline derivatives | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1989-05-02 | — | — | US | disclosed |