Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.36 |
| ▸ | FDPS | P14324 | 14/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9720201 | 0.93 | PPARG (0.36) | MEN1HSP90AA1KMT2ASMN1; SMN2PPARG | |
| Hydrochloric Acid SCHEMBL10384998 | 0.91 | MEN1 (0.41) | MEN1HSP90AA1KMT2ASMN1; SMN2FDPS | |
| Hydrochloric Acid SCHEMBL9720174 | 0.87 | MEN1 (0.36) | MEN1HSP90AA1KMT2ASMN1; SMN2FDPS | |
| Hydrochloric Acid SCHEMBL9716351 | 0.85 | TLR2 (0.36) | MEN1HSP90AA1KMT2ASMN1; SMN2FDPS | |
| SCHEMBL29367255 | 0.84 | FDPS (0.35) | MEN1HSP90AA1KMT2ASMN1; SMN2PPARG | |
| Hydrochloric Acid SCHEMBL10384997 | 0.83 | MEN1 (0.36) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| Hydrochloric Acid SCHEMBL9720170 | 0.82 | MEN1 (0.34) | MEN1HSP90AA1KMT2ASMN1; SMN2FDPS | |
| Hydrochloric Acid SCHEMBL10384985 | 0.81 | PLA2G2A (0.32) | APAF1NPSR1 | |
| Hydrochloric Acid SCHEMBL9720212 | 0.78 | PPARG (0.40) | PPARGPPARA | |
| Hydrochloric Acid SCHEMBL10384984 | 0.77 | APAF1 (0.47) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5081245-A | Selective antitumor agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-01-14 | — | — | US | disclosed |
| EP-0356765-A2 | Carboxylic acid derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1990-03-07 | — | — | EP | disclosed |