Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | PLA2G2C | Q5R387 | 4/20 | 0.33 |
| ▸ | TLR2 | O60603 | 4/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.32 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9720236 | 0.87 | CES2 (0.38) | CES2TSHRPLA2G2APLA2G2CTLR2 | |
| SCHEMBL9720217 | 0.86 | MEN1 (0.51) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL10554872 | 0.80 | HTT (0.59) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL10552354 | 0.80 | HTT (0.59) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL9720251 | 0.80 | PLA2G2A (0.35) | CES2PLA2G2APLA2G2CTLR2ALDH1A1 | |
| SCHEMBL16405345 | 0.80 | CES2 (0.49) | MAPTCES2PLA2G2APLA2G2CLMNA | |
| SCHEMBL9720173 | 0.79 | HTT (0.49) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL29521479 | 0.75 | MEN1 (0.58) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL3501786 | 0.75 | MEN1 (0.58) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL5146487 | 0.75 | MEN1 (0.62) | MEN1KMT2ATHRBHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5081245-A | Selective antitumor agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-01-14 | — | — | US | disclosed |
| EP-0356765-A2 | Carboxylic acid derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1990-03-07 | — | — | EP | disclosed |