Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | SHBG | P04278 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8105720 | 0.83 | HSP90AB1 (0.41) | HSP90AB1CYP3A4POLBSHBGRAB9A | |
| SCHEMBL18535886 | 0.83 | HSP90AB1 (0.41) | HSP90AB1CYP3A4POLBSHBGRAB9A | |
| SCHEMBL28159519 | 0.82 | LMNA (0.46) | CYP3A4POLBRAB9AALDH1A1KDM4E | |
| SCHEMBL7450427 | 0.79 | HSP90AB1 (0.47) | HSP90AB1POLBALDH1A1KDM4EMEN1 | |
| SCHEMBL11574084 | 0.78 | HSP90AB1 (0.43) | HSP90AB1POLBALDH1A1KDM4EMEN1 | |
| SCHEMBL15133627 | 0.78 | NPC1 (0.40) | HSP90AB1POLBRAB9AKDM4EMEN1 | |
| SCHEMBL28385050 | 0.78 | HSP90AB1 (0.46) | HSP90AB1CYP3A4POLBALDH1A1KDM4E | |
| SCHEMBL30093973 | 0.77 | CYP4F2 (0.55) | ALDH1A1MEN1KMT2AMAPK1CYP4F2 | |
| SCHEMBL9712335 | 0.77 | ALDH1A1 (0.38) | CYP3A4ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL27544752 | 0.77 | CSNK2A2 (0.49) | CYP3A4POLBRAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5103022-A | Reacting dl-2-methyl-1-(4-trifluoromethylphenyl)-3-pyrrolidino -1-propanone with l-acetylphenylglycine to form corresponding diastereomeric salt, deposition, isolation of l-2-methyl-1-(4-trifluoromethylphenyl)-3-pyrrolidino-1-propanone | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1992-04-07 | — | — | US | disclosed |
| US-5057535-A | Muscle relaxants | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1991-10-15 | — | — | US | disclosed |
| EP-0200942-A2 | New derivatives of an aminoketone | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1986-11-12 | — | — | EP | disclosed |