Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 3/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9720789 | 0.88 | PDCD1 (0.42) | PDCD1CD274PDK2DHODHESR2 | |
| SCHEMBL9720773 | 0.87 | PDCD1 (0.43) | PDCD1CD274PDK2DHODHESR2 | |
| SCHEMBL9720745 | 0.85 | DHODH (0.38) | PDK2DHODHESR2LMNATAAR1 | |
| SCHEMBL9720784 | 0.84 | ESR2 (0.43) | PDCD1CD274PDK2ESR2HTT | |
| SCHEMBL9720758 | 0.84 | PDCD1 (0.41) | PDCD1CD274PDK2DHODHLMNA | |
| SCHEMBL9720787 | 0.80 | ESR2 (0.42) | PDCD1CD274PDK2ESR2HTT | |
| SCHEMBL9720754 | 0.76 | PDCD1 (0.42) | PDCD1CD274PDK2DHODHLMNA | |
| SCHEMBL18621557 | 0.76 | PDCD1 (0.44) | PDCD1CD274PDK2ESR2LMNA | |
| SCHEMBL9720833 | 0.74 | CYP11B1 (0.55) | — | |
| SCHEMBL780417 | 0.74 | PTPRC (0.50) | PDK2ESR2LMNATAAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5149707-A | 1-((2-FLUOROPHENYL)(4-FLUOROPHENYL)PHENYLMETHYL)-1H-IMIDAZOLE USEFUL AS ANTIFUNGAL AGENT | J. URIACH & CIA, S.A. (ES) | 1992-09-22 | — | — | US | disclosed |
| EP-0352352-B1 | 1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole | J. URIACH & CIA. S.A. (ES) | 1991-10-16 | — | — | EP | disclosed |
| EP-0352352-A1 | 1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole | J. URIACH & CIA. S.A. (ES) | 1990-01-31 | — | — | EP | disclosed |