⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL160251 | 0.79 | — | — | |
| SCHEMBL15063829 | 0.78 | — | — | |
| SCHEMBL6486806 | 0.76 | — | — | |
| SCHEMBL260518 | 0.74 | — | — | |
| SCHEMBL27496672 | 0.71 | PTGS2 (0.41) | — | |
| SCHEMBL29212774 | 0.70 | TUBB1 (0.31) | — | |
| SCHEMBL15063635 | 0.67 | GABRA1 (0.31) | — | |
| SCHEMBL8386937 | 0.67 | LMNA (0.31) | — | |
| SCHEMBL1068238 | 0.67 | CA2 (0.37) | — | |
| SCHEMBL596981 | 0.67 | APOBEC3G (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 356 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115232175-B | Fluorine-containing quasi-C2 symmetrical silicon bridged metallocene complex and application thereof | 山东金诚石化集团有限公司 | 2024-06-14 | — | — | CN | claimed |
| CN-115368417-A | Fluorine-containing C1 symmetric silicon bridged metallocene complex and application thereof | 山东清河化工科技有限公司 | 2022-11-22 | — | — | CN | claimed |
| CN-115232175-A | Fluorine-containing quasi-C2 symmetric silicon bridged metallocene complex and application thereof | 山东清河化工科技有限公司 | 2022-10-25 | — | — | CN | claimed |
| CN-108026094-B | Substituted 4-azaindoles and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2021-02-09 | — | — | CN | claimed |
| EP-3319963-B1 | SUBSTITUTED 4-AZAINDOLES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-01-08 | — | — | EP | claimed |
| CN-106220572-B | Pyridazine derivative compound, application, composition and kit and preparation method | 因西必泰克新有限公司 | 2019-12-13 | — | — | CN | claimed |
| US-10377753-B2 | Substituted 4-azaindoles and their use as GluN2B receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2019-08-13 | — | — | US | claimed |
| EP-3243815-B1 | PYRIDAZINE DERIVATIVES USEFUL IN THERAPY | INHIBITAXIN LTD (GB) | 2019-07-10 | — | — | EP | claimed |
| US-10016420-B2 | Substituted pyridazines for the treatment of pain | INHIBITAXIN LIMITED (GB) | 2018-07-10 | — | — | US | claimed |
| EP-3319963-A1 | SUBSTITUTED 4-AZAINDOLES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2018-05-16 | — | — | EP | claimed |
| US-20050113423-A1 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED | 2005-05-26 | — | — | US | claimed |
| US-20050096376-A1 | Substituted 3-pyrrolidine-indole derivatives | GRUENENTHAL GMBH (DE) | 2005-05-05 | — | — | US | claimed |
| JP-2005511694-A | — | — | 2005-04-28 | — | — | JP | claimed |
| US-20050014815-A1 | Substituted 2-pyrrolidine-2-yl-1H-indole compounds | GRUENENTHAL GMBH (DE) | 2005-01-20 | — | — | US | claimed |
| US-20040192916-A1 | Substituted 1-oxa-2,8-diaza-spiro[4,5]dec-2-ene derivatives and related treatment methods | GRUENENTHAL GMBH (DE) | 2004-09-30 | — | — | US | claimed |
| WO-2004080972-A1 | PIRAZOLE MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-09-23 | — | — | WO | claimed |
| EP-1451177-A1 | SUBSTITUTED 2-PYRROLIDINE-2-YL-1H-INDOLE DERIVATIVES FOR THE TREATMENT OF MIGRAINE | Grünenthal GmbH (DE) | 2004-09-01 | — | — | EP | claimed |
| EP-1401841-A1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | Grünenthal GmbH (DE) | 2004-03-31 | — | — | EP | claimed |
| WO-2003048156-A1 | SUBSTITUTED 2-PYRROLIDINE-2-YL-1H-INDOLE DERIVATIVES FOR THE TREATMENT OF MIGRAINE | Grünenthal GmbH (DE) | 2003-06-12 | — | — | WO | claimed |
| WO-2003000699-A1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO[4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | Grünenthal GmbH (DE) | 2003-01-03 | — | — | WO | claimed |