Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.37 |
| ▸ | ERN1 | O75460 | 7/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9721275 | 0.82 | TLR8 (0.40) | TLR8ERN1HSD17B1HSD17B2CHEK1 | |
| SCHEMBL9721307 | 0.81 | ERN1 (0.38) | ERN1 | |
| SCHEMBL9721313 | 0.79 | ERN1 (0.41) | ERN1ESR1 | |
| SCHEMBL9721333 | 0.75 | ERN1 (0.42) | ERN1 | |
| SCHEMBL9721235 | 0.71 | ERN1 (0.41) | ERN1 | |
| SCHEMBL9721297 | 0.69 | CA1 (0.43) | TLR8HSD17B1HSD17B2ESR2ESR1 | |
| SCHEMBL9721232 | 0.69 | APP (0.46) | ERN1 | |
| SCHEMBL13623366 | 0.66 | ERN1 (0.58) | ERN1 | |
| SCHEMBL9721278 | 0.65 | KDM4E (0.40) | ERN1 | |
| SCHEMBL9721322 | 0.65 | CYP3A4 (0.40) | ERN1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | claimed |
| WO-1990011988-A1 | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-18 | — | — | WO | claimed |
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | disclosed |