Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9721418 | 0.87 | CA1 (0.36) | CA1CA2TLR8LMNAHTT | |
| SCHEMBL9721291 | 0.84 | TLR8 (0.36) | CA1CA2TLR8ADORA3ALDH1A1 | |
| SCHEMBL9721302 | 0.78 | TLR8 (0.35) | CA1CA2TLR8LMNAHTT | |
| SCHEMBL922255 | 0.75 | CA1 (0.56) | CA1CA2ALDH1A1MAPTMEN1 | |
| SCHEMBL9721311 | 0.74 | MAOA (0.36) | TLR8ESR1ESR2CYP3A4PIM1 | |
| Ethane SCHEMBL28865517 | 0.71 | CA1 (0.50) | CA1CA2LMNAHTTALDH1A1 | |
| SCHEMBL278777 | 0.70 | CA1 (0.54) | CA1CA2TLR8ALDH1A1MAPT | |
| SCHEMBL9721357 | 0.69 | TLR8 (0.37) | TLR8ESR1ESR2HSD17B1HSD17B2 | |
| Ethane SCHEMBL28219675 | 0.69 | CA1 (0.48) | CA1CA2LMNAHTTALDH1A1 | |
| SCHEMBL9571457 | 0.69 | CA1 (0.59) | CA1CA2LMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | claimed |
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | disclosed |
| WO-1990011988-A1 | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-18 | — | — | WO | disclosed |