SCHEMBL9722128

SCHEMBL9722128

O=C(O)C1CC2(CCC34C=CC(C3)C(C(=O)O)C4)C=CC1C2

nearest known ligand 0.32

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GRM4 Q14833 4/20 0.32
CYP2C19 P33261 2/20 0.32
TDP1 Q9NUW8 2/20 0.32
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
CYP1A2 P05177 1/20 0.32
KMT2A Q03164 1/20 0.32
GRM8 O00222 1/20 0.32
GRM6 O15303 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
GRM2 Q14416 1/20 0.30
GRM3 Q14832 1/20 0.30
POLB P06746 1/20 0.30
APEX1 P27695 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28115075 0.85 GRM2 (0.32) GRM4CYP2C19TDP1MEN1ALDH1A1
SCHEMBL7050131 0.75 LMNA (0.40) CYP2C19MEN1ALDH1A1KMT2ACYP2D6
SCHEMBL23426218 0.72
SCHEMBL7048008 0.71 HTR7 (0.36)
SCHEMBL31533275 0.71 APLNR (0.35) GRM4CYP2C19TDP1MEN1ALDH1A1
SCHEMBL7047190 0.70
SCHEMBL8051059 0.67 GRM2 (0.34) GRM4CYP2C19TDP1MEN1ALDH1A1
SCHEMBL7047127 0.63
SCHEMBL5833342 0.53 POLB (0.48) TDP1GRM2POLBAPEX1
SCHEMBL22361971 0.53 POLB (0.48) TDP1GRM2POLBAPEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5096644-A Process for making a filled metathesis polymer article HERCULES INCORPORATED (US) 1992-03-17 US disclosed
US-5068296-A Crosslinked copolymers for molding materials HERCULES INCORPORATED (US) 1991-11-26 US disclosed
US-5006616-A Metathesis polymerized copolymer HERCULES INCORPORATED (US) 1991-04-09 US disclosed
US-4994535-A Molding material HERCULES INCORPORATED (US) 1991-02-19 US disclosed
US-4923943-A DICYCLOPENTADIENE, NORBORNENYL ESTERS OF NORBORNENYL ACIDS HERCULES INCORPORATED (US) 1990-05-08 US disclosed
US-4918138-A Process for producing a colored molded article of metathesis polymerized polymer HERCULES INCORPORATED (US) 1990-04-17 US disclosed
EP-0349855-A2 Molded article of metathesis polymerized polymer containing fillers and process for its preparation HERCULES INCORPORATED (US) 1990-01-10 EP disclosed
EP-0329063-A2 Process for producing a colored molded article of metathesis polymerized polymer HERCULES INCORPORATED (US) 1989-08-23 EP disclosed
EP-0305933-A2 Process for producing a molded article of metathesis polymerized polymer HERCULES INCORPORATED (US) 1989-03-08 EP disclosed
EP-0287762-A2 Methathesis polymerized copolymer HERCULES INCORPORATED (US) 1988-10-26 EP disclosed
EP-0286839-A1 Metathesis polymerized copolymer HERCULES INCORPORATED (US) 1988-10-19 EP disclosed
EP-0283719-A2 Metathesis polymerized cross-linked halogen-containing copolymer HERCULES INCORPORATED (US) 1988-09-28 EP disclosed
EP-0280247-A2 Metathesis polymerization HERCULES INCORPORATED (US) 1988-08-31 EP disclosed