Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.67 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.67 |
| ▸ | ACHE | P22303 | 1/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.67 |
| ▸ | HTR2A | P28223 | 1/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9722093 | 0.84 | LMNA (0.68) | CYP2D6LMNASIGMAR1KCNH2NR1I2 | |
| SCHEMBL9722157 | 0.83 | LMNA (0.67) | CYP2D6LMNASIGMAR1KCNH2NR1I2 | |
| SCHEMBL9721975 | 0.83 | LMNA (0.67) | CYP2D6LMNASIGMAR1KCNH2NR1I2 | |
| SCHEMBL9722004 | 0.83 | LMNA (0.67) | CYP2D6LMNASIGMAR1KCNH2NR1I2 | |
| SCHEMBL6906283 | 0.82 | CYP2D6 (0.65) | CYP2D6LMNASIGMAR1KCNH2NR1I2 | |
| SCHEMBL9722000 | 0.81 | ACHE (0.64) | CYP2D6LMNASIGMAR1KCNH2NR1I2 | |
| Butenafine SCHEMBL20456391 | 0.80 | CYP2D6 (1.00) | CYP2D6LMNASIGMAR1KCNH2NR1I2 | |
| Butenafine SCHEMBL29354083 | 0.80 | CYP2D6 (1.00) | CYP2D6LMNASIGMAR1KCNH2NR1I2 | |
| Butenafine SCHEMBL65526 | 0.80 | CYP2D6 (1.00) | CYP2D6LMNASIGMAR1KCNH2NR1I2 | |
| Butenafine SCHEMBL676912 | 0.79 | LMNA (0.97) | CYP2D6LMNASIGMAR1KCNH2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310122-B1 | ANTIFUNGAL COMPOSITION | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1991-07-24 | — | — | EP | claimed |
| EP-0310122-A1 | Antifungal composition | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1989-04-05 | — | — | EP | claimed |
| US-5120735-A | Synergistic mixture of miconazole, ketoconazole or fluconazole and N-4-tertbutylbenzyl-N-methyl-1-naphthalenemethylamine | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1992-06-09 | — | — | US | disclosed |
| EP-0310122-B1 | ANTIFUNGAL COMPOSITION | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1991-07-24 | — | — | EP | disclosed |
| EP-0310122-A1 | Antifungal composition | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1989-04-05 | — | — | EP | disclosed |