Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MITF | O75030 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | HMGCR | P04035 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.31 |
| ▸ | TUBB | P07437 | 1/20 | 0.31 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.31 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.31 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9796412 | 0.78 | NPC1 (0.44) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL9796430 | 0.76 | HPGDS (0.42) | MAPTALDH1A1LMNAHTTKMT2A | |
| SCHEMBL9796460 | 0.76 | GSK3B (0.35) | ALDH1A1LMNAHTTSMN1; SMN2MITF | |
| SCHEMBL8895170 | 0.75 | MAPT (0.43) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL9796449 | 0.74 | RAB9A (0.46) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL9796468 | 0.73 | SMN1; SMN2 (0.40) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL9722968 | 0.73 | MEN1 (0.38) | MAPTALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL9796262 | 0.72 | HTT (0.51) | MAPTALDH1A1LMNAHTTMEN1 | |
| SCHEMBL9722918 | 0.72 | HMGCR (0.36) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL9722953 | 0.72 | MEN1 (0.39) | MAPTALDH1A1LMNASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997840-A | Quinolone sulphonates having antihypertensive activity | THE BOOTS COMPANY, PLC (GB) | 1991-03-05 | — | — | US | disclosed |
| WO-1989007593-A1 | THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1989-08-24 | — | — | WO | disclosed |