Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Xylose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.35 |
| ▸ | MPI | P34949 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | TOP1 | P11387 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Xylose SCHEMBL23066320 | 1.00 | LMNA (0.46) | LMNAL3MBTL1TDP1AKR1B1KDM4E | |
| Xylose SCHEMBL20298307 | 1.00 | LMNA (0.46) | LMNAL3MBTL1TDP1AKR1B1KDM4E | |
| Xylose SCHEMBL17376028 | 1.00 | LMNA (0.46) | LMNAL3MBTL1TDP1AKR1B1KDM4E | |
| Xylose SCHEMBL27662059 | 1.00 | LMNA (0.46) | LMNAL3MBTL1TDP1AKR1B1KDM4E | |
| Xylose SCHEMBL624787 | 1.00 | LMNA (0.46) | LMNAL3MBTL1TDP1AKR1B1KDM4E | |
| Xylose SCHEMBL9824366 | 0.98 | LMNA (0.43) | LMNAL3MBTL1TDP1AKR1B1KDM4E | |
| Demannose SCHEMBL2341216 | 0.96 | LMNA (0.48) | LMNAL3MBTL1TDP1AKR1B1KDM4E | |
| Demannose SCHEMBL9938071 | 0.96 | LMNA (0.48) | LMNAL3MBTL1TDP1AKR1B1KDM4E | |
| Demannose SCHEMBL329074 | 0.93 | LMNA (0.50) | LMNAL3MBTL1TDP1AKR1B1KDM4E | |
| Xylose SCHEMBL5322348 | 0.93 | LMNA (0.43) | LMNAL3MBTL1TDP1AKR1B1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5100921-A | Antibiotics with bactericide, fungicide and antiprotozoa activity | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-03-31 | — | — | US | disclosed |
| US-4945108-A | Angucyclinones from streptomycetes, a process for the preparation thereof, and the use thereof | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-07-31 | — | — | US | disclosed |