Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.43 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9724282 | 0.85 | KMT2A (0.57) | LMNAPKMKDM4EALDH1A1ADORA3 | |
| SCHEMBL9724144 | 0.81 | LMNA (0.48) | LMNAPKMKDM4EALDH1A1ADORA3 | |
| SCHEMBL9383680 | 0.81 | NPC1 (0.41) | LMNAPKMKDM4EALDH1A1ADORA3 | |
| SCHEMBL24538005 | 0.78 | LMNA (0.62) | LMNAPKMKDM4EALDH1A1MEN1 | |
| SCHEMBL15450991 | 0.75 | DYRK1A (0.51) | LMNAKDM4EALDH1A1ADORA3DYRK1A | |
| SCHEMBL3350745 | 0.75 | LMNA (0.62) | LMNAPKMKDM4EALDH1A1MEN1 | |
| SCHEMBL5989580 | 0.73 | KMT2A (0.56) | LMNAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL1592575 | 0.73 | LMNA (0.51) | LMNAPKMKDM4EALDH1A1MEN1 | |
| SCHEMBL16930396 | 0.73 | DYRK1A (0.53) | LMNAKDM4EALDH1A1ADORA3DYRK1A | |
| SCHEMBL9724191 | 0.73 | LMNA (0.58) | LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112837-A | Inhibitors of thymidylate synthetase enzyme | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-05-12 | — | — | US | disclosed |
| EP-0318225-A2 | 6-Aryl aminomethyl quinoline derivatives and their use as anti-tumour agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-05-31 | — | — | EP | disclosed |