Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | GRM2 | Q14416 | 15/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27623216 | 0.88 | GRM2 (0.69) | LMNAGRM2 | |
| SCHEMBL3350745 | 0.87 | LMNA (0.62) | LMNAGRM2PKMGPR35 | |
| SCHEMBL16833045 | 0.81 | ALDH1A1 (0.58) | LMNAGRM2SMN1; SMN2 | |
| SCHEMBL6004248 | 0.81 | GRM2 (0.54) | LMNAGRM2 | |
| SCHEMBL9729781 | 0.80 | ALDH1A1 (0.55) | LMNAPKMSMN1; SMN2 | |
| SCHEMBL2708959 | 0.79 | GRM2 (0.63) | LMNAGRM2 | |
| SCHEMBL9724269 | 0.78 | GRM2 (0.43) | LMNAGRM2 | |
| SCHEMBL16833596 | 0.77 | NQO2 (0.61) | GRM2SMN1; SMN2 | |
| SCHEMBL2908229 | 0.76 | GPR35 (0.55) | LMNAGRM2GPR35 | |
| SCHEMBL17827033 | 0.75 | LMNA (0.68) | LMNARAD52SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112837-A | Inhibitors of thymidylate synthetase enzyme | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-05-12 | — | — | US | disclosed |
| EP-0318225-A2 | 6-Aryl aminomethyl quinoline derivatives and their use as anti-tumour agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-05-31 | — | — | EP | disclosed |