Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | GNG2 | P59768 | 2/20 | 0.56 |
| ▸ | GNB1 | P62873 | 2/20 | 0.56 |
| ▸ | MMP1 | P03956 | 1/20 | 0.56 |
| ▸ | MMP9 | P14780 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | APAF1 | O14727 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | UBE2N | P61088 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3651398 | 0.84 | MEN1 (0.57) | KMT2AMEN1GNG2GNB1MMP1 | |
| SCHEMBL3645814 | 0.83 | NPC1 (0.66) | KMT2AMEN1MMP1MMP9NPC1 | |
| SCHEMBL7763069 | 0.82 | GNG2 (0.81) | KMT2AMEN1GNG2GNB1MMP1 | |
| SCHEMBL5989371 | 0.81 | TERT (0.60) | KMT2AMEN1GNG2GNB1MMP1 | |
| SCHEMBL13754217 | 0.80 | LMNA (0.60) | KMT2AMEN1GNG2GNB1MMP1 | |
| SCHEMBL3738216 | 0.80 | DOT1L (0.57) | KMT2AMEN1GNG2GNB1MMP1 | |
| SCHEMBL31672140 | 0.80 | DOT1L (0.57) | KMT2AMEN1GNG2GNB1MMP1 | |
| SCHEMBL6468321 | 0.78 | EGFR (0.54) | KMT2AMEN1NPC1MAPTKDM4E | |
| SCHEMBL4748569 | 0.76 | LMNA (0.58) | KMT2ALMNANPC1SMN1; SMN2MAPT | |
| SCHEMBL13697268 | 0.75 | KMT2A (0.61) | KMT2AMEN1GNG2GNB1MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060030565-A1 | Amide derivatives and nociceptin antagonists | JAPAN TOBACCO INC. | 2006-02-09 | — | — | US | disclosed |
| US-6903094-B2 | Amide derivatives and nociceptin antagonists | JAPAN TABACCO, INC. (JP) | 2005-06-07 | — | — | US | disclosed |
| US-20030055087-A1 | Amide derivatives and nociceptin antagonists | JAPAN TOBACCO INC. | 2003-03-20 | — | — | US | disclosed |
| US-6410561-B1 | ANALGESICS | JAPAN TOBACCO INC. (JP) | 2002-06-25 | — | — | US | disclosed |
| CN-1301154-A | Amide derivatives and nociceptin antagonists | JAPAN TOBACCO INC (JP) | 2001-06-27 | — | — | CN | disclosed |
| EP-1072263-A1 | AMIDE DERIVATIVES AND NOCICEPTIN ANTAGONISTS | JAPAN TOBACCO INC. (JP) | 2001-01-31 | — | — | EP | disclosed |
| US-4014877-A | MICROBIOCIDES | RIKER LABORATORIES, INC. (US) | 1977-03-29 | — | — | US | disclosed |
| US-4001243-A | ANTI-MICROBIAL | RIKER LABORATORIES, INC. (US) | 1977-01-04 | — | — | US | disclosed |
| US-3985882-A | ADMISTERING | RIKER LABORATORIES, INC. (US) | 1976-10-12 | — | — | US | disclosed |
| US-3969463-A | MICROBIOCIDE | RIKER LABORATORIES, INC. (US) | 1976-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055087-A1 | Amide derivatives and nociceptin antagonists | OPRL1, OPRD1, OPRK1 | KMT2A 1535/4885MEN1 4480/4885GNG2 715/4885 |
| US-20060030565-A1 | Amide derivatives and nociceptin antagonists | OPRL1, OPRD1, OPRM1 | KMT2A 1262/4885MEN1 4423/4885GNG2 710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.