Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9724203 | 0.80 | MAPT (0.63) | MAPTLMNAPOLBNR4A2L3MBTL1 | |
| SCHEMBL5514349 | 0.77 | MAPT (0.51) | MAPTLMNAPOLBNR4A2L3MBTL1 | |
| SCHEMBL10519226 | 0.74 | MAPT (0.56) | MAPTLMNAPOLBNR4A2L3MBTL1 | |
| SCHEMBL9380126 | 0.73 | LMNA (0.62) | MAPTLMNAPOLBNR4A2L3MBTL1 | |
| SCHEMBL5026883 | 0.70 | MAPT (0.56) | MAPTLMNAPOLBNR4A2L3MBTL1 | |
| SCHEMBL9216843 | 0.69 | KDM4E (0.55) | MAPTLMNAPOLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL9494656 | 0.68 | LMNA (0.96) | MAPTLMNAPOLBL3MBTL1CYP1A2 | |
| SCHEMBL24658982 | 0.68 | MAPT (0.53) | MAPTLMNAPOLBNR4A2L3MBTL1 | |
| SCHEMBL4913124 | 0.68 | ALDH1A1 (0.54) | MAPTLMNAPOLBCYP1A2ALDH1A1 | |
| SCHEMBL6605146 | 0.68 | MAPT (0.49) | MAPTLMNAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112837-A | Inhibitors of thymidylate synthetase enzyme | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-05-12 | — | — | US | disclosed |
| EP-0318225-A2 | 6-Aryl aminomethyl quinoline derivatives and their use as anti-tumour agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-05-31 | — | — | EP | disclosed |