Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | ITGAL | P20701 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 2/20 | 0.30 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL15054537 | 0.98 | PKM (0.37) | PKMTSHRABCG2ITGB2ICAM1 | |
| SCHEMBL9834913 | 0.82 | PKM (0.34) | PKMTSHR | |
| SCHEMBL295321 | 0.81 | PKM (0.38) | PKMTSHRABCG2ITGB2ICAM1 | |
| SCHEMBL9768971 | 0.81 | PKM (0.38) | PKMTSHRABCG2ITGB2ICAM1 | |
| SCHEMBL293833 | 0.78 | PKM (0.36) | PKMTSHRABCG2ITGB2ICAM1 | |
| SCHEMBL8309740 | 0.78 | PKM (0.36) | PKMTSHRABCG2ITGB2ICAM1 | |
| SCHEMBL3430194 | 0.78 | PKM (0.37) | PKMTSHRMAOBLMNAKDM4E | |
| SCHEMBL17361793 | 0.77 | HTR2C (0.42) | — | |
| SCHEMBL4564855 | 0.77 | TSHR (0.35) | PKMTSHRABCG2ITGB2ICAM1 | |
| SCHEMBL9768795 | 0.77 | HTR7 (0.35) | PKMTSHRABCG2ITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5158948-A | Treating neurological and psychological disorders | ABBOTT LABORATORIES (US) | 1992-10-27 | — | — | US | disclosed |
| US-5025013-A | Antiarrhythmia or antifibrillatory agents | RHONE-POULENC SANTE (FR) | 1991-06-18 | — | — | US | disclosed |
| US-4994470-A | Antiarrhthmia agents | RHONE-POULENC SANTE (FR) | 1991-02-19 | — | — | US | disclosed |
| US-4977166-A | ANTIARRHYTHMIC AND ANTIFIBRILLATORY AGENTS | RHONE-POULENC SANTE (FR) | 1990-12-11 | — | — | US | disclosed |
| EP-0157267-B1 | SUBSTITUTED BENZOPYRANS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICINES | BAYER AG (DE) | 1988-11-23 | — | — | EP | disclosed |
| EP-0148666-B1 | PROCESS FOR PREPARING HYDROXY-3-METHYL-3 GLUTARIC ACID | SANOFI (FR) | 1987-05-20 | — | — | EP | disclosed |
| US-4659737-A | Substituted aminomethyl benzopyrans having anti-hypertensive activities | BAYER AKTIENGESELLSCHAFT (DE) | 1987-04-21 | — | — | US | disclosed |
| EP-0114374-B1 | SUBSTITUTED 4-AMINOMETHYLENE CHROMANS OR CHROMENES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICINES | BAYER AG (DE) | 1986-07-23 | — | — | EP | disclosed |
| US-4563458-A | CIRCULATORY SYSTEM DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1986-01-07 | — | — | US | disclosed |
| EP-0157267-A2 | Substituted benzopyrans, process for their preparation and their use in medicines | BAYER AG (DE) | 1985-10-09 | — | — | EP | disclosed |
| EP-0148666-A1 | Process for preparing hydroxy-3-methyl-3 glutaric acid | SANOFI (FR) | 1985-07-17 | — | — | EP | disclosed |
| EP-0114374-A1 | Substituted 4-aminomethylene chromans or chromenes, process for their preparation and their use in medicines | BAYER AG (DE) | 1984-08-01 | — | — | EP | disclosed |