Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 2/20 | 0.32 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | KDM4A | O75164 | 1/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5671309 | 0.80 | SIGMAR1 (0.38) | GRM2GRM3HPGDMETAP1EPHX1 | |
| SCHEMBL10701341 | 0.78 | GRM2 (0.44) | GRM2GRM3HPGDCYP2D6METAP1 | |
| SCHEMBL8745906 | 0.78 | GRM2 (0.44) | GRM2GRM3HPGDCYP2D6METAP1 | |
| SCHEMBL5670650 | 0.77 | SIGMAR1 (0.34) | HPGDMETAP1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8745883 | 0.77 | GRM2 (0.42) | GRM2GRM3HPGDCYP2D6METAP1 | |
| SCHEMBL27620522 | 0.73 | GGT1 (0.46) | GRM2GRM3HPGDCYP2D6METAP1 | |
| SCHEMBL3620882 | 0.71 | CYP1A2 (0.53) | GRM2GRM3HPGDCYP2D6METAP1 | |
| SCHEMBL27620442 | 0.71 | GGT1 (0.47) | GRM2GRM3HPGDCYP2D6METAP1 | |
| Hydrochloric Acid SCHEMBL4798850 | 0.70 | CYP1A2 (0.52) | GRM2GRM3HPGDCYP2D6METAP1 | |
| SCHEMBL8818939 | 0.70 | SIGMAR1 (0.46) | HPGDEPHX1SIGMAR1KDM5APHF8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114927-A | Hypotensive agents and inhibiting renin | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-05-19 | — | — | US | disclosed |