Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.49 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.49 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17659883 | 0.81 | TXNRD1 (0.50) | TXNRD1TXNRD3TXNRD2KMT2AMEN1 | |
| SCHEMBL8403277 | 0.75 | ALDH1A1 (0.43) | TXNRD1TXNRD3TXNRD2KMT2AMEN1 | |
| SCHEMBL5239589 | 0.75 | TXNRD1 (0.68) | TXNRD1TXNRD3TXNRD2KMT2AMEN1 | |
| SCHEMBL12341984 | 0.74 | NQO2 (0.42) | POLBNQO2ALDH1A1CYP19A1SMN1; SMN2 | |
| SCHEMBL1028694 | 0.72 | MAPT (0.62) | TXNRD1TXNRD3TXNRD2KMT2AMEN1 | |
| SCHEMBL4918988 | 0.71 | TDP1 (0.52) | KMT2AMEN1MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL17659043 | 0.71 | MAPT (0.50) | TXNRD1TXNRD3TXNRD2KMT2AMEN1 | |
| SCHEMBL8403300 | 0.71 | TXNRD1 (0.68) | TXNRD1TXNRD3TXNRD2KMT2AMEN1 | |
| SCHEMBL30330095 | 0.71 | CYP1A2 (0.51) | TXNRD1TXNRD3TXNRD2KMT2AMEN1 | |
| SCHEMBL17241149 | 0.71 | TXNRD1 (0.47) | TXNRD1TXNRD3TXNRD2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5082848-A | Gastrointestinal disorders | SMITH KLINE & FRENCH LABORATORIES, LTD. (GB) | 1992-01-21 | — | — | US | disclosed |
| EP-0331357-A1 | 4-Amino-3-acylquinoline derivatives and their use as inhibitors of gastric secretion | SMITHKLINE BECKMAN INTERCREDIT B.V. (NL) | 1989-09-06 | — | — | EP | disclosed |