Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.43 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971652 | 0.83 | ADRB1 (0.62) | ADRB1KDM4EL3MBTL1CYP2D6PPARG | |
| SCHEMBL12968838 | 0.81 | ADRB1 (0.68) | ADRB1KDM4EL3MBTL1CYP2D6PPARG | |
| SCHEMBL18176129 | 0.79 | ADRB1 (0.73) | ADRB1KDM4EL3MBTL1CYP2D6PPARG | |
| SCHEMBL3140922 | 0.78 | DRD4 (0.53) | DRD2DRD3ALDH1A1PIK3C3DPP4 | |
| SCHEMBL7130750 | 0.78 | ADRB1 (0.59) | ADRB1KDM4EL3MBTL1CYP2D6FFAR4 | |
| SCHEMBL24008459 | 0.77 | ADRB1 (0.71) | ADRB1KDM4EL3MBTL1CYP2D6PPARG | |
| SCHEMBL31061118 | 0.76 | CXCR3 (0.52) | ADRB1KDM4EL3MBTL1CYP2D6PPARG | |
| SCHEMBL2799020 | 0.76 | ADRA1B (0.52) | ADRB1KDM4EL3MBTL1CYP2D6DRD2 | |
| SCHEMBL1901605 | 0.76 | ADRB1 (0.69) | ADRB1KDM4EL3MBTL1CYP2D6PPARG | |
| SCHEMBL1998032 | 0.76 | ADRB1 (0.69) | ADRB1KDM4EL3MBTL1CYP2D6PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135931-A | Antidepressants, psychological disorders, nervous system disorders | AKZO N.V. (NL) | 1992-08-04 | — | — | US | disclosed |
| EP-0462638-A1 | Pyridinylpiperazine derivatives | Akzo Nobel N.V. (NL) | 1991-12-27 | — | — | EP | disclosed |