SCHEMBL972512

SCHEMBL972512

COc1cc(-c2onc(C)c2C)ccc1S(=O)(=O)NCc1ccc(C)o1

nearest known ligand 0.63

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TP53 P04637 9/20 0.63
MAPT P10636 6/20 0.51
POLB P06746 1/20 0.50
BRD4 O60885 1/20 0.44
BRD2 P25440 1/20 0.44
BRD3 Q15059 1/20 0.44
KMT2A Q03164 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL972405 0.84 KMT2A (0.59) TP53MAPTKMT2A
SCHEMBL972037 0.78 MAPT (0.61) TP53MAPTPOLBKMT2A
SCHEMBL18292427 0.74 TP53 (0.68) TP53MAPTPOLBBRD4BRD2
SCHEMBL2307738 0.70 MAPT (0.80) TP53MAPTPOLBBRD4BRD2
SCHEMBL972981 0.64 ALDH1A1 (0.52) TP53MAPTPOLBKMT2A
SCHEMBL6773708 0.62 EDNRA (0.82)
SCHEMBL972519 0.61 TP53 (0.62) TP53MAPTPOLBKMT2A
SCHEMBL6665358 0.61 TSHR (0.65) POLBBRD4BRD2BRD3
SCHEMBL12169323 0.61 KMT2A (0.57) MAPTPOLBKMT2A
SCHEMBL8748534 0.59 MAPK1 (0.51) MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110015065-A1 Substituted Sulfonic Acid Amide Compounds BASF SE (DE) 2011-01-20 US claimed
EP-2252590-A1 SUBSTITUTED SULFONIC ACID AMIDE COMPOUNDS BASF SE (DE) 2010-11-24 EP claimed
WO-2009101082-A1 SUBSTITUTED SULFONIC ACID AMIDE COMPOUNDS BASF SE (DE) 2009-08-20 WO claimed
US-20110015065-A1 Substituted Sulfonic Acid Amide Compounds BASF SE (DE) 2011-01-20 US disclosed
EP-2252590-A1 SUBSTITUTED SULFONIC ACID AMIDE COMPOUNDS BASF SE (DE) 2010-11-24 EP disclosed
WO-2009101082-A1 SUBSTITUTED SULFONIC ACID AMIDE COMPOUNDS BASF SE (DE) 2009-08-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110015065-A1 Substituted Sulfonic Acid Amide Compounds STS, NAPA, NAAA TP53 783/4885MAPT 3640/4885POLB 4080/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.