Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.47 |
| ▸ | CTSS | P25774 | 3/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL969820 | 0.85 | MMP2 (0.46) | — | |
| SCHEMBL19376965 | 0.81 | ITGB3 (0.43) | CTSKCTSSJAK3BTK | |
| SCHEMBL3730954 | 0.81 | ITGB3 (0.43) | CTSKCTSSJAK3BTK | |
| SCHEMBL12947678 | 0.81 | CTSK (0.54) | CTSKCTSSCTSLCTSBACE | |
| SCHEMBL16296285 | 0.80 | ITGB3 (0.42) | CTSKCTSSJAK3BTK | |
| SCHEMBL19033478 | 0.79 | CTSK (0.55) | CTSKCTSSCTSLCTSBACE | |
| Putrescine SCHEMBL28493581 | 0.79 | ACE (0.69) | CTSKCTSSCTSLCTSBACE | |
| Lysine SCHEMBL29140134 | 0.79 | ACE (0.60) | CTSKCTSSCTSLCTSBACE | |
| SCHEMBL11038198 | 0.79 | ACE (0.60) | CTSKCTSSCTSLCTSBACE | |
| SCHEMBL3789929 | 0.79 | CTSS (0.59) | CTSKCTSSCTSLCTSBACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120115950-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | SHIRE LLC (US) | 2012-05-10 | — | — | US | disclosed |
| US-20110009669-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | SHIRE LLC (US) | 2011-01-13 | — | — | US | disclosed |
| US-20100197798-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | SHIRE LLC (US) | 2010-08-05 | — | — | US | disclosed |
| US-7723305-B2 | Abuse-resistant amphetamine prodrugs | SHIRE LLC (US) | 2010-05-25 | — | — | US | disclosed |
| US-7718619-B2 | Abuse-resistant amphetamine prodrugs | SHIRE LLC (US) | 2010-05-18 | — | — | US | disclosed |
| US-7713936-B2 | Abuse-resistant amphetamine prodrugs | SHIRE LLC (US) | 2010-05-11 | — | — | US | disclosed |
| US-7700561-B2 | Abuse-resistant amphetamine prodrugs | SHIRE LLC (US) | 2010-04-20 | — | — | US | disclosed |
| US-7687467-B2 | Abuse-resistant amphetamine prodrugs | SHIRE LLC (US) | 2010-03-30 | — | — | US | disclosed |
| US-7687466-B2 | Abuse-resistant amphetamine prodrugs | SHIRE LLC (US) | 2010-03-30 | — | — | US | disclosed |
| US-7678770-B2 | Abuse-resistant amphetamine prodrugs | SHIRE LLC (US) | 2010-03-16 | — | — | US | disclosed |
| US-20090131333-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | SHIRE LLC (US) | 2009-05-21 | — | — | US | disclosed |
| US-20090131334-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | SHIRE LLC (US) | 2009-05-21 | — | — | US | disclosed |
| US-20090131332-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | SHIRE LLC (US) | 2009-05-21 | — | — | US | disclosed |
| US-20090131335-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | SHIRE LLC (US) | 2009-05-21 | — | — | US | disclosed |
| US-20090131322-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | SHIRE LLC (US) | 2009-05-21 | — | — | US | disclosed |
| US-20090131325-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | SHIRE LLC (US) | 2009-05-21 | — | — | US | disclosed |
| US-20090124831-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | SHIRE LLC (US) | 2009-05-14 | — | — | US | disclosed |
| US-20090124696-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | SHIRE LLC (US) | 2009-05-14 | — | — | US | disclosed |
| US-20090124700-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | SHIRE LLC (US) | 2009-05-14 | — | — | US | disclosed |
| US-20070042955-A1 | Abuse-resistant amphetamine prodrugs | NEW RIVER PHARMACEUTICALS INC. (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131322-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | COMT, CYP3A5, CYP2D6 | CTSK 1897/4885CTSS 1737/4885CTSL 1445/4885 |
| US-20090131332-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | COMT, CYP3A5, CYP2D6 | CTSK 1897/4885CTSS 1737/4885CTSL 1445/4885 |
| US-20070042955-A1 | Abuse-resistant amphetamine prodrugs | COMT, CYP3A5, CYP2D6 | CTSK 1897/4885CTSS 1737/4885CTSL 1445/4885 |
| US-20090124700-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | COMT, CYP3A5, CYP2D6 | CTSK 1897/4885CTSS 1737/4885CTSL 1445/4885 |
| US-20090124696-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | COMT, CYP3A5, CYP2D6 | CTSK 1897/4885CTSS 1737/4885CTSL 1445/4885 |
| US-20090131333-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | COMT, CYP3A5, CYP2D6 | CTSK 1897/4885CTSS 1737/4885CTSL 1445/4885 |
| US-20120115950-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | COMT, CYP3A5, CYP2D6 | CTSK 1897/4885CTSS 1737/4885CTSL 1445/4885 |
| US-20100197798-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | COMT, CYP3A5, CYP2D6 | CTSK 1897/4885CTSS 1737/4885CTSL 1445/4885 |
| US-20090131325-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | COMT, CYP3A5, CYP2D6 | CTSK 1897/4885CTSS 1737/4885CTSL 1445/4885 |
| US-20090124831-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | COMT, CYP3A5, CYP2D6 | CTSK 1897/4885CTSS 1737/4885CTSL 1445/4885 |
| US-20090131334-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | COMT, CYP3A5, CYP2D6 | CTSK 1897/4885CTSS 1737/4885CTSL 1445/4885 |
| US-20090131335-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | COMT, CYP3A5, CYP2D6 | CTSK 1897/4885CTSS 1737/4885CTSL 1445/4885 |
| US-20110009669-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | COMT, CYP3A5, CYP2D6 | CTSK 1897/4885CTSS 1737/4885CTSL 1445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.