Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | CCR6 | P51684 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | MGLL | Q99685 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4810587 | 1.00 | TNF (0.47) | TNFLMNACCR6L3MBTL1ADORA2A | |
| SCHEMBL4254776 | 0.93 | CCR6 (0.49) | TNFLMNACCR6L3MBTL1ADORA2A | |
| SCHEMBL7321782 | 0.85 | ADORA2A (0.46) | LMNAL3MBTL1ADORA2APDE4APDE4B | |
| SCHEMBL5687930 | 0.83 | PDE4A (0.47) | TNFLMNAADORA2APDE4APDE4B | |
| SCHEMBL4251917 | 0.80 | PDE4A (0.46) | LMNACCR6L3MBTL1ADORA2APDE4A | |
| SCHEMBL4255826 | 0.79 | CASP6 (0.46) | TNFLMNACCR6L3MBTL1ADORA2A | |
| SCHEMBL8175084 | 0.77 | ADORA2A (0.48) | TNFLMNACCR6L3MBTL1ADORA2A | |
| SCHEMBL4811164 | 0.73 | ALDH1A1 (0.60) | LMNAL3MBTL1PDE4APDE4BPDE4C | |
| SCHEMBL4963710 | 0.72 | MGLL (0.52) | TNFLMNAADORA2BMAPK1TSHR | |
| SCHEMBL11840543 | 0.72 | MGLL (0.52) | TNFLMNAADORA2BMAPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4217672-A | — | — | None | — | — | JP | disclosed |
| JP-H04217672-A | 2,4-PYRIMIDINEDIONE DERIVATIVE AND MEDICAMENT COMPOSITION | SANOFI SA | 1992-08-07 | — | — | JP | disclosed |