Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.64 |
| ▸ | DRD2 | P14416 | 5/20 | 0.64 |
| ▸ | HTR2A | P28223 | 4/20 | 0.64 |
| ▸ | HTR7 | P34969 | 2/20 | 0.64 |
| ▸ | HTR6 | P50406 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | GMNN | O75496 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726193 | 0.94 | HTR7 (0.73) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9726205 | 0.94 | HTR2A (0.70) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9726198 | 0.84 | DRD2 (0.70) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL7793840 | 0.76 | HTR2A (0.59) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9726206 | 0.74 | HTR2A (0.62) | HTR1ADRD2HTR2AHTR7HTR6 | |
| Rp-68303 SCHEMBL9635292 | 0.73 | KDM4E (0.60) | HTR2ALMNASLC6A4ALDH1A1MAPT | |
| SCHEMBL9726221 | 0.73 | HTR2A (0.64) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL7793847 | 0.71 | SLC6A4 (1.00) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL4850144 | 0.69 | HTR2A (0.47) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9726239 | 0.67 | HTR2A (0.57) | HTR1ADRD2HTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130313-A | Central nervous system disorders, cardiovascular disorders or gastrointestinal disorders | RHONE-POULENC SANTE (FR) | 1992-07-14 | — | — | US | disclosed |