Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.73 |
| ▸ | HTR2A | P28223 | 3/20 | 0.73 |
| ▸ | DRD2 | P14416 | 3/20 | 0.73 |
| ▸ | HTR1A | P08908 | 2/20 | 0.73 |
| ▸ | HTR6 | P50406 | 2/20 | 0.73 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 2/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | HTR5A | P47898 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726205 | 0.98 | HTR2A (0.70) | HTR7HTR2ADRD2HTR1AHTR6 | |
| SCHEMBL9726243 | 0.94 | HTR1A (0.64) | HTR7HTR2ADRD2HTR1AHTR6 | |
| SCHEMBL9726198 | 0.88 | DRD2 (0.70) | HTR7HTR2ADRD2HTR1AHTR6 | |
| SCHEMBL9726221 | 0.78 | HTR2A (0.64) | HTR7HTR2ADRD2HTR1AHTR6 | |
| SCHEMBL9726206 | 0.77 | HTR2A (0.62) | HTR7HTR2ADRD2HTR1AHTR6 | |
| SCHEMBL7793840 | 0.74 | HTR2A (0.59) | HTR7HTR2ADRD2HTR1AHTR6 | |
| SCHEMBL9726239 | 0.72 | HTR2A (0.57) | HTR7HTR2ADRD2HTR1AHTR6 | |
| SCHEMBL8011318 | 0.71 | DRD2 (0.69) | HTR2ADRD2HTR1ASLC6A4DRD4 | |
| SCHEMBL7793815 | 0.70 | SLC6A4 (0.80) | HTR7HTR2ADRD2HTR1AHTR6 | |
| Fananserin SCHEMBL340722 | 0.69 | HTR7 (1.00) | HTR7HTR2ADRD2HTR1AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130313-A | Central nervous system disorders, cardiovascular disorders or gastrointestinal disorders | RHONE-POULENC SANTE (FR) | 1992-07-14 | — | — | US | disclosed |