Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | HTR1D | P28221 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727223 | 0.81 | HTR7 (0.71) | HTR7HTR1AHTR1DDRD2DRD3 | |
| SCHEMBL9727207 | 0.79 | CHRM2 (0.55) | DRD2DRD3 | |
| SCHEMBL14591377 | 0.78 | HTR1D (0.51) | HTR7HTR1AHTR1DGRIN2B | |
| SCHEMBL7935409 | 0.78 | HTR1D (0.51) | HTR7HTR1AHTR1DGRIN2BOPRM1 | |
| SCHEMBL14591337 | 0.78 | HTR1D (0.51) | HTR7HTR1AHTR1DGRIN2B | |
| SCHEMBL7932835 | 0.77 | HTR7 (0.69) | HTR7HTR1AHTR1DDRD2 | |
| SCHEMBL11072209 | 0.77 | HTR7 (0.69) | HTR7HTR1AHTR1DDRD2 | |
| SCHEMBL9727205 | 0.76 | GRIN2B (0.68) | HTR7HTR1ADRD2GRIN2BOPRM1 | |
| Hydrochloric Acid SCHEMBL7926756 | 0.76 | HTR7 (0.67) | HTR7HTR1AHTR1DDRD2 | |
| SCHEMBL4215401 | 0.76 | CHRM2 (0.55) | HTR1DDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164385-A | AZETIDINE DERIVATIVES AND HYPOTENSIVE COMPOSITIONS THEREOF | JOHN WYETH & BROTHER, LTD. (GB) | 1992-11-17 | — | — | US | claimed |
| US-5164385-A | AZETIDINE DERIVATIVES AND HYPOTENSIVE COMPOSITIONS THEREOF | JOHN WYETH & BROTHER, LTD. (GB) | 1992-11-17 | — | — | US | disclosed |